Few artists of her generation show themselves to be as versatile with a wide variety of repertoire as Christina Landshamer, which has made her a concert, opera and lieder singer in demand around the world today. Her collaboration with conductors such as Herbert Blomstedt, Manfred Honeck, Alan Gilbert, Marek Janowski, Franz Welser-Möst and Christian Thielemann has led her to such important orchestras as the Bavarian Radio Symphony Orchestra, the NDR Elbphilharmonie Orchestra Hamburg, the Gewandhaus Orchestra Leipzig, the SWR Symphony Orchestra Stuttgart, the Munich and Berlin Philharmonic Orchestras, the Concertgebouw Orkest Amsterdam, the Tonhalle Orchestra Zurich, the Orchestre de Paris, the Accademia Nationale di Santa Cecilia Rome and the Swedish Radio Orchestra Stockholm. In the USA and Canada she has appeared with the New York Philharmonic Orchestra, the Pittsburgh Symphony Orchestra and the Montreal Symphony Orchestra.

Early opera engagements took the soprano to the Stuttgart State Opera, the Opéra du Rhin in Strasbourg and the Komische Oper Berlin, as well as to the Theater an der Wien under Nikolaus Harnoncourt and to the Salzburg Festival under Sir Simon Rattle. She sang Pamina at the Bavarian State Opera and Het Muziektheater Amsterdam in Simon McBurney's Magic Flute, Ännchen in the new production of Weber's Freischütz under Christian Thielemann at the Semperoper Dresden, Almirena/Rinaldo at Glyndebourne and Sophie/Rosenkavalier at the Lyric Opera of Chicago. At the Bavarian State Opera, Christina Landshamer most recently sang Woglinde in Wagner's Rheingold under Kirill Petrenko and Pamina in Mozart's Magic Flute. She also appeared in a spectacular La Fura-dels Baus production of Haydn's Creation in Paris and at the Mostly Mozart Festival in New York.

With her warm, lyrical soprano voice, Christina Landshamer is also an ideal Lied singer: together with her piano partner Gerold Huber, she is a welcome guest at Lied centres such as the Schubertiade Schwarzenberg, Berlin's Pierre Boulez Hall, Wigmore Hall London, Weill Recital Hall, Carnegie Hall New York or Kioi Hall Tokyo. She was also invited by Thomas Hampson to perform a Schubert programme in Berlin's Pierre Boulez Hall.

More than 50 CD and DVD recordings for labels such as Decca, Deutsche Grammophon, Sonymusic, Pentatone, BR Klassik, Oehms Classics, Phi, EMI, Accentus, Unitel etc. document Christina Landshamer's artistic activity.

Since 2021, she has also been appointed professor of singing at the Hochschule für Musik Trossingen.